Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells
نویسندگان
چکیده
منابع مشابه
AR-V7 Expression Predicts Prostate Cancer Outcomes
Radical prostatectomy (RP) specimens with unfavorable pathol‐ ogy increased over nine years, but the reasons remain unclear, according to a study reported at the American Urological Asso‐ cia on (AUA) 2016 Annual Mee ng. Results were reported by Katherine Rotker, MD, of Brown University in Providence, RI. Following US Preven ve Health Services Task Force (USPSTF) 2009 and 2012 recommenda ons ag...
متن کاملAndrogen receptor splice variant V7 (AR-V7) in circulating tumor cells: a coming of age for AR splice variants?
Prostate cancer continues to be the most common non-cutaneous malignancy afflicting men in developed countries [1]. Although surgery or radiotherapy for the primary disease appears be curative at the time of initial treatment, upward of 25% of men will have metastatic or residual disease (ACS Facts and Figures 2015). Since the advent of prostate-specific antigen assays, the recurrence of the ca...
متن کاملAndrogen Receptor Variant AR-V9 Is Coexpressed with AR-V7 in Prostate Cancer Metastases and Predicts Abiraterone Resistance.
Purpose: Androgen receptor (AR) variant AR-V7 is a ligand-independent transcription factor that promotes prostate cancer resistance to AR-targeted therapies. Accordingly, efforts are under way to develop strategies for monitoring and inhibiting AR-V7 in castration-resistant prostate cancer (CRPC). The purpose of this study was to understand whether other AR variants may be coexpressed with AR-V...
متن کاملDroplet Digital PCR Based Androgen Receptor Variant 7 (AR-V7) Detection from Prostate Cancer Patient Blood Biopsies
Androgen receptor splice variant V7 (AR-V7) was recently identified as a valuable predictive biomarker in metastatic castrate-resistant prostate cancer. Here, we report a new, sensitive and accurate screen for AR-V7 mRNA expression directly from circulating tumor cells (CTCs): We combined EpCAM-based immunomagnetic CTC isolation using the IsoFlux microfluidic platform with droplet digital polym...
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1802415115